Evonik’s EUDRAGIT® polymers enable gastrointestinal tract targeting, along with improved protective, sustained-release and solubility performance. Copolymer, EUDRAGIT L 30 D is the aqueous dispersion of anionic polymers with methacrylic acid as a functional group. Physical properties: It is a. Pellets were coated with Eudragit L 30 D using fluidized bed processor. Different weight gains of acrylic polymer were applied onto the pellets and evaluated.
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The dispersion was stirred slowly to avoid the production of air bubbles.
Poly methacrylic acid-co-ethyl acrylate 1: The packed bulk density was calculated as the quotient of the weight and volume sedimented. In preliminary trials, various formulation combinations Table 3 and conditions including spheronization speed, amount of granulating liquid, and spheronization time were investigated to produce spherical and smooth surface pellets Table 2.
The results indicated that it is possible to prevent the acidic degradation of sod PAS in upper GI tract which ultimately affect the bioavailability of drug and will help to reduce the dose, by development of multiparticulate system coated with pH dependent polymers using extrusion spheronization technique and fluidized bed processor.
A burst effect has so far not been reported with multiparticulate systems. Fluidized bed coater performed enteric coating. The cumulative percent drug release-time profiles were determined.
Data sheets for overmetals, plastics, ceramics, and composites. The carboxylic groups ionize in aqueous media at pH 5. Microcrystalline cellulose was used as filler in concentration of A speed of rpm was selected as optimized speed for the production of spherical and smooth surface pellets.
The percentage friability was calculated from the pellet weight before and after fluidization [ 8 ].
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Subscribe to Premium Services Searches: Subcoating of pellets is done to improve acid resistance of entericcoated dosage forms. Glcerylmonostearate dispersion in methylene chloride was used for this purpose and was prepared by adding the powder to the solvent. The total out put of extrudate is mainly governed by the extrusion speed. The particles were vacuumed, dried and coated with gold palladium and observed microscopically. Ten percent aqueous solution of PEG 8.
Subscribe to our Newsletter All our latest content delivered to your inbox. With increase in MCC content, surface of pellets had more plastic nature due to accommodate an increased granulating liquid thus they could be easily deformed during spheronization.
Evonik EUDRAGIT® L 30 D Copolymer
Twenty grams of pellets were poured gradually through a funnel into a 50 ml graduated cylinder, tapped 50 times using USP density test apparatus.
The angle of repose was measured using funnel with 6 mm diameter orifice 20 g of pellets were placed in funnel and allowed to fall 4 cm onto a hard level surface.
Hence it was decided to give a seal coat to protect the drug. Scanning electron micrograph of developed pellets. Property Data This page displays only the text of a material data sheet. Developed system was found to be suitable for the delivery of Sod PAS in to intestinal region.
Twenty grams of pellets were poured gradually through a funnel in to 50 ml graduated cylinder, tapped lightly on hard surface and the volume measured.
The acrylic polymer coating suspensions were prepared by adding water to the commercially available Eudragit L30 D Media were agitated at rpm and samples were taken at regular intervals, filtered through ll30. The pellets were fluidized for 15 min. Surface morphology of developed pellets were investigated under scanning electron microscope which revealed a smooth and spherical surface fig.
The wet mass was extruded with a Fauji Paudal granulator through a 1. In vitro release of sod PAS eudrwgit coated pellets with different weight gain.