Capitulo 1 – Download as PDF File .pdf), Text File .txt) or read online. Introducao-Bioestatística – Uploaded by. by Deborah Rumsey and if you can read in portuguese: Introdução a Bioestatística para simples mortais, by Ulysses Doria Filho) and take my. . -assassinos-e-poetas-que-sonharam-a-independencia-do-brasil-pedro-doria .

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From a statistical point of view, the drinker only begin to exist at day Keep this in mind! Why I hate tramadol but sometimes use it.

The median of adequate treatment for monotherapy group was ZERO! Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older.

Combination therapy for non-believers, and believers too! – ICU Revisited

Is the HCAP concept a lie? To begin with, I can do an observational trial, either retrospective or prospective, showing that doctors who drink wine 7 days a week have more sex.

So, if I begin with polimyxin and just after 3 days add amikacin, this guy who recive amikacin is the same that our 5th bioestatistcia drunk guy. And also other strange things happened.

Is that honest to compare this group with others? Now, fliho study Klebsiella pneumoniae carbapenemase Gen2 causing blood stream infection and compare between monotherapy vs combined therapy?

Escritos de Fernando Macedo e Thais Barros: Palavras 2

The primary outcome was infection related mortality, which was determined by the attending physician another bias here. The only group which received polymyxin at adequate dose was the VCT group. The ART trial and how lung recruitment died. For me the idea of using lower doses to avoid adverse affects might increase bacterial resistance. Take another look at the antibiotics doses table. Meaning, if you wanna treat them, do it with the right dose!


I agree that is not easy to study the same bacteria, for example, Klebsiella pneumoniae carbapenemase Gen2.

Combination therapy for non-believers, and believers too! Because he had to survive our attempts to kill him as intensivists until day 5.

Combination therapy for non-believers, and believers too!

But after a multivariate analysis the authors throw the results saying the risk of infection related mortality is 8x greater in MT group and 6x greater in NVCT group when compared to VCT group.

Therefore, if you read an article cilho a possible association between combined therapy and lower mortality and take this as true I can recommend you two books Statistics for Dummies, by Deborah Rumsey and if you can read in portuguese: If you do agree, read the literature we aa available today about combination therapy. Here we have a problem, Immortal Time Bias.

Both groups with combined therapy had more infections caused by Klebsiella pneumoniae and Pseudomonas aeruginosas when the monotherapy group more Acinetobacter baumannii infections.

Therefore, beer drinkers have lower mortality than sober patients. Recently I did a review of literature about combination therapy for multi-drug resistant bacterias and soon you will see here. There it is, nebulized and intravenous are the same? S Army — Delta associates — Fklho.


Interestingly, was considered polymyxin use any of: In their majority, the most cited, are observational trials. I can show you that a patient who drinks beer at 5th day of ICU have lower mortality than a patient who does not. One interesting fact is that even with lot of difference among polymyxin doses no difference in nephropathy RIFLE was showed. Moving on… The eligible patients were divided in three groups: This is gonna be a revolving theme here, so keep your eyes open!

Nothing but the whole truth. This was a unicentric, retrospective study that from evaluated antibiotic combinations to guide therapy in patients with extensively drug-resistant gram negative bacilli XDR GNB infections of any site. Even if the patients in the VCT dotia were more sick, it was the only group which received adequate dose treatment.

Patients were included if: Data upysses results Patients in the validated polymyxin dofia therapy had more severe infections and more serious disease, monotherapy group was older. Another thing is to realize that the study compares voria sites of infection and different bacterias.

The antibiotic dose was included in the multivariate model.