Lonomia obliqua venom and hemolymph have been shown to contain molecules that, besides interfering in blood coagulation (for a review, Veiga et al. ). Lonomia obliqua (Walker, ) is a moth from the family Saturniidae, widely distributed in tropical rainforests of South America. In its larval stage (caterpillar) it . Rev Assoc Med Bras (). May-Jun;61(3) doi: / Lonomia obliqua Walker (Lepidoptera: Saturniidae): hemostasis .

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The species became internationally known when an epidemic occurred in an agrarian community in Rio Grande do Sul. In the case of ponomia poisoning, report this immediately to the health authorities nearest to the site where the poisoning took place as they are more likely to have immediate access to anti-lonomia horse serum. To increase cell yield, many procedures are used, such as supplementing the culture medium with nutrients and mitogenic activators, minimizing the presence of toxic metabolites such as lactate and ammonia, and preventing the lack of oxygen.

The negative control was treated with 0. The diagnosis of poisoning is made based on the patient’s medical history, clinical manifestations, erythrocyte levels, and, primarily, parameters that evaluate blood coagulation. Among animals known to produce pharmacologically active molecules that interfere in human cell physiology, the caterpillar Lonomia obliqua has become the focus of toxicological studies due to recent findings about its venom constituents.

The reported death rate obliquz 2.

Intracerebral haemorrhage after contact with Lonomia caterpillars. Along with the note was the green caterpillar which was hidden inside lonomix her slipper. Venom samples were prepared from bristles as described in Veiga et al.

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Lonomia obliqua Walker, is a moth from the family Lonoia, widely distributed in tropical rainforests of South America. This page was last edited on 10 Novemberat These results suggest that the bristle extract contains both pro- and anti-proliferative activities that act differently depending on the cell type. Large-scale production of human adipose tissue from stem cells: Acute kidney injury associated with lymphangitic carcinomatosis.


Suitability of human mesenchymal stem cells for gene therapy depends on the expansion medium.

Lonomia obliqua Walker (Lepidoptera: Saturniidae): hemostasis implications.

Ceramide in nitric oxide inhibition oblqua glioma cell growth. It effectively reverses the coagulation disorders induced by Lonomia obliqua venom, and patients treated with this antiserum recover rapidly. Hematoma and gangrene -like symptoms manifested, spreading throughout the body, eventually causing massive blood leakage into the brain and, in several cases, death.

Short daily dialysis for 2 h per day was continued for the next three consecutive days. In another case, internal bleeding spread throughout the lower body.

Can Ibliqua Physiol Pharmacol.

Conflict of interest The authors declare that there are no conflicts of interest. However, when V cells were treated with the same doses and the dose lohomia 0. Tissue Eng Part C Methods.

This anti-clotting agent would attach to another protein of the body’s cells and cause them to leak as blood is unable to clot. An active component which showed the ability to strongly and selectively inhibit the viability of V cells suggests that the same isolated molecule could have a greater effect on these cells and perhaps in obljqua lineages, including even some tumor cells, which would have an application against cancer.

Caterpillars of many species can cause irritation by their hollow body hairs that envenom or detach easily, or can be poisonous if ingested; [4] however, prior to investigations obliwua Lonomia caterpillars, it was not known that caterpillars could produce toxins which in sufficient quantities could kill a human being.


The minimization of apoptosis has considerable interest for biotechnological applications.

Lonomia obliqua – Wikipedia

Considering the results obtained in cell viability analysis, we performed experiments of cell counting to verify if the increase in the number of UMG viable cells was due to an increase in cell proliferation.

Further studies encompassing the purification of active principles from L. It is known that NO has an important role in the progression of gliomas Himlin et al.

Canadian Medical Association Journal. MTT analysis of cells treated with L. Novel perspectives on the pathogenesis of Lonomia obliqua caterpillar envenomation based on assessment of host response by gene expression analysis.

All experiments were performed at least three times. Retrieved from ” https: While there are more than a dozen species in the genus, the most troublesome species is Lonomia obliquaand it is this species on which most of the medical research has centered. Lonomia obliqua has a toxic venom which causes disseminated intravascular coagulation and a consumptive coagulopathy, which can lead to a hemorrhagic syndrome.

Author information Article notes Copyright and License information Disclaimer. Lonomia obliqua crude bristle extract was added to the culture medium of cells cultured in the presence or absence of FBS cells in proliferation or quiescence, respectively.

The present study shows that L.

Statistical analysis All experiments were performed at least three times.